Sa will be joined in the midfield by Guy Armitage who came on as a replacement in the Premiership fixture two weeks ago. Darren Allinson and Shane Geraghty will partner at half back. Geraghty will also captain the side. Tom Fowlie, Andrew Fenby and Alex Lewington make up the back three.
Matt Parr, Mike Mayhew and Jamie Hagan will start in the front row with Ben Toolis, who joins on loan from Edinburgh, and Kieran Low in the second row. Declan Danaher, Blair Cowan and Danny Kenny, who joins London Irish on trial, make up the back row.
Brian Smith, Exiles Director of Rugby said: “The LV=Cup presents us with a chance to mix the squad up a little bit and allow those that have had limited game time an opportunity to show what they can do. The boys have worked hard this week and want to go up there and put in a performance.”
London Irish team to face Newcastle Falcons:
15. Alex Lewington; 14.Tom Fowlie; 13. Guy Armitage; 12. Setaimata Sa*; 11. Andrew Fenby; 10. Shane Geraghty (Captain); 9. Darren Allinson; 1. Matt Parr; 2. Mike Mayhew; 3. Jamie Hagan; 4. Ben Toolis; 5. Kieran Low; 6. Declan Danaher; 7. Danny Kenny; 8. Blair Cowan
Replacements: 16. Richard Palframan; 17 Johnny Harris; 18. Leo Halavatau; 19.Bryn Evans*; 20. Ben Lonergan; 21. Fergus Mulchrone; 22. Myles Dorrian; 23. Ed Hoadley