Jonny Harris, Jimmy Stevens and Leo Halavatau make up the front row. Scott Moore will join former Nottingham player Nic Rouse in the second row. Gerard Ellis and Sean O'Connell will partner Declan Danaher in the back row. Danaher will captain the side.
USA U20s captain Tom Bliss, who is currently training with the Exiles, will start at scrum half and partner Myles Dorrian. Eamonn Sheridan is joined by Ian Cross in the centres. Alex Lewington, Andrew Fenby and Topsy Ojo make up the back three.
London Irish Director of Rugby, Brian Smith, said: "Friday night gives us the opportunity to give the new signings and a few of the young lads a run out against a very strong opposition. This allows us to explore these new combinations in a pressured environment. Players not involved this week will get their chance against Wasps and Munster."
London Irish team to face Nottingham
15. Topsy Ojo; 14. Alex Lewington; 13.Ian Cross; 12. Eamonn Sheridan; 11. Andrew Fenby; 10. Myles Dorrian; 9. Tom Bliss; 1. Jonny Harris; 2. Jimmy Stevens; 3. Leo Halavatau; 4. Scott Moore; 5. Nic Rouse; 6. Gerard Ellis; 7. Declan Danaher (Captain); 8. Sean O'Connell
Replacements: Scott Tolmie; Tom Smallbone; Richard Palframan; Charlie Davey; George Owen; Ed Hoadley
Tom Bliss, Andy Tuilagi and Scott Tolmie are all currently training with London Irish