<1r>The Exiles will be looking to continue their fine start to the Aviva Premiership campaign at Kingston Park, where they are unbeaten in their last six visits.
London Irish go into the match in second place in the Premiership and have once again opted for consistency as they name an unchanged starting line up for the second time this season.
The only squad change sees Samoan winger Sailosi Tagicakibau selected on the bench after missing the past two matches with a sprained ankle.
Speaking about the contest, Booth said: “I was very pleased with the manner of our victory over Gloucester last weekend. Once again we were defensively excellent and very dominant in the scrum.
“We have spoken about the different challenges of playing away from home against teams like Newcastle, and as a squad we are very clear what we need to do to be successful, both individually and collectively.”
London Irish: 15. Delon Armitage*; 14. Topsy Ojo*; 13. Seilala Mapusua *; 12. Daniel Bowden; 11. Jonathan Joseph; 10. Ryan Lamb; 9. Paul Hodgson*; 1. Clarke Dermody* (captain); 2. James Buckland; 3. Faan Rautenbach*; 4. Nick Kennedy*; 5. Bob Casey*; 6. Kieran Roche; 7. Declan Danaher ; 8. George Stowers*.
Replacements: 16. David Paice; 17. Max Lahiff; 18. Alex Corbisiero; 19. Matt Garvey; 20. Jonathon Fisher; 21. Sailosi Tagicakibau*; 22. Chris Malone; 23. Darren Allinson.
Head Coach: Toby Booth; Attack Coach: Mike Catt; Defence Coach: Dave Ellis.
For regular updates on the match follow London Irish's official Twitter page at www.twitter.com/lirfc
There will also be live match commentary from Kingston Park by Graham McKechnie of BBC Radio Berkshire on the London Irish website and the match will be broadcast live on Sky Sports.